Search results for " Interleukin-13"

showing 3 items of 3 documents

The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis

2008

The nuclear factor of activated T cells (NFAT) family of transcription factors controls calcium signaling in T lymphocytes. In this study, we have identified a crucial regulatory role of the transcription factor NFATc2 in T cell–dependent experimental colitis. Similar to ulcerative colitis in humans, the expression of NFATc2 was up-regulated in oxazolone-induced chronic intestinal inflammation. Furthermore, NFATc2 deficiency suppressed colitis induced by oxazolone administration. This finding was associated with enhanced T cell apoptosis in the lamina propria and strikingly reduced production of IL-6, -13, and -17 by mucosal T lymphocytes. Further studies using knockout mice showed that IL-…

Adjuvants Immunologic; Animals; Humans; Interleukin-13; Interleukin-17; Interleukin-6; Lymphocyte Activation; Mice; Mice Inbred BALB C; Mice Knockout; Mice SCID; Models Biological; NFATC Transcription Factors; Oxazolone; T-LymphocytesT cellT-LymphocytesImmunologyMice SCIDBiologyLymphocyte ActivationInflammatory bowel diseaseModels BiologicalArticleOxazoloneTCIRG1chemistry.chemical_compoundMiceAdjuvants ImmunologicmedicineImmunology and AllergyCytotoxic T cellAnimalsHumansColitisMice KnockoutMice Inbred BALB CInterleukin-13NFATC Transcription FactorsInterleukin-6Interleukin-17OxazoloneArticlesmedicine.diseasemedicine.anatomical_structurechemistryImmunologyInterleukin 13Cancer researchInterleukin 17The Journal of Experimental Medicine
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CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children.

2005

BACKGROUND In atopic dermatitis (AD) a Th1/Th2 imbalance has been reported, and interleukin (IL)-13 seems to play a pivotal role in the inflammatory network. We tried to assess the correlation between the immunological marker CD4(+)IL-13(+) and the clinical phase of extrinsic AD in children. METHODS Twenty children with AD were studied. Assessed parameters were: clinical severity (SCORAD index), total serum immunoglobulin E (IgE), blood eosinophil count, and percentage of CD4(+)IFNgamma(+), CD4(+)IL-4(+), CD4(+)IL-13(+) T cells. Determinations were carried out in the acute phase and after clinical remission were achieved. Ten nonatopic-matched children served as controls. RESULTS At baselin…

CD4-Positive T-LymphocytesMaleAllergyImmunologyCD4 T cellsEosinophilSettore MED/10 - Malattie Dell'Apparato Respiratoriointerleukin-13Immunoglobulin ESeverity of Illness IndexDermatitis AtopicSettore MED/13 - EndocrinologiaAtopyLeukocyte CountImmunopathologymedicineHumansImmunology and AllergySCORADChildmedicine.diagnostic_testbiologyatopic dermatitisbusiness.industrySeverity of Illness Index; Interleukin-13; Dermatitis Atopic; Humans; Child; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Leukocyte Count; Child Preschool; Eosinophils; Immunoglobulin E; Case-Control Studies; Female; MaleInterleukinallergy; atopic dermatitis; CD4 T cells; interleukin-13; Th1/Th2 cellsAtopic dermatitisEosinophilImmunoglobulin Emedicine.diseaseallergyCD4 Lymphocyte CountEosinophilsmedicine.anatomical_structureCD4-Positive T-LymphocyteCase-Control StudiesChild PreschoolImmunologybiology.proteinFemaleTh1/Th2 cellsbusinessCase-Control StudieHuman
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IL-13 receptor α 2: A regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts

2005

Background IL-13 and IL-4 share many functional properties as a result of their use of a common receptor complex comprising IL-13 receptor α 1 (IL-13Rα1) and IL-4 receptor α (IL-4Rα). The nonsignaling receptor IL-13 receptor α 2 (IL-13Rα2) binds IL-13 with high affinity and specificity and is believed to be a decoy receptor for IL-13. Objective We sought to examine the inhibitory effects of soluble and membrane-bound IL-13Rα2 on IL-13– and IL-4–mediated effects. Methods Primary human fibroblasts were grown from endobronchial biopsy specimens obtained from volunteers. Upregulation of IL-13Rα2 mRNA was measured by means of RT-PCR, and the level of surface expression was measured by means of F…

Interleukin 2medicine.medical_specialtyReceptor complexmedicine.medical_treatmentImmunologyGene ExpressionBronchiBiologyDownregulation and upregulationInternal medicinemedicineHumansImmunology and AllergyRNA MessengerReceptorCells CulturedInterleukin-13Reverse Transcriptase Polymerase Chain ReactionReceptors Interleukin-13FibroblastsFlow CytometryUp-RegulationCell biologyEndocrinologyCytokineInterleukin 13STAT proteinInterleukin-4Signal transductionSignal Transductionmedicine.drugJournal of Allergy and Clinical Immunology
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